Bioinformatics

Recent Trends in 'Computational Omics: Concepts and Methodology'

Recent Trends in 'Computational Omics: Concepts and Methodology'

Author: Pramod Katara

Publisher:

ISBN: 1536179418

Category: Bioinformatics

Page: 478

View: 946

The last decade has witnessed various technological advances in life sciences, especially high throughput technologies. These technologies provide a way to perform parallel scientific studies in a very short period of time with low cost. High throughput techniques, mainly, next generation sequencing, microarray and mass spectrometry, have strengthened the omics vision in the last decades (study of complete system) and now resulted in well-developed branches of omics i.e., genomics, transcriptomics, proteomics and metabolomics, which deal with almost every level of central dogma of life. Practice of high throughput techniques throughout the world with different aims and objectives resulted in a voluminous data, which required computational applications, i.e., database, algorithm and software to store, process and get biological interpretation from primary raw data. Researchers from different fields are looking to analyze these raw data for different purposes, but lacking of proper information and knowledge in proper documented form creates different kinds of hurdles and raises the challenges. This book contains thirteen chapters that deal with different computational biology/bioinformatics resources and concepts which are already in practice by the scientific community or can be utilized to handle various aspects of different classes of omics data. It includes different computational concepts, algorithm, resources and recent trends belonging to the four major branches of omics (i.e., genomics, transcriptomics, proteomics and metabolomics), including integrative omics. It will help all scholars who are working in any branch of computational omics and bioinformatics field as well as those who would like to perform research at a systemic biology through computational approaches.
Business & Economics

Bioinformatics

Bioinformatics

Author: Dev Bukhsh Singh

Publisher: Academic Press

ISBN: 9780323900058

Category: Business & Economics

Page: 510

View: 543

Bioinformatics: Methods and Applications provides a thorough and detailed description of principles, methods, and applications of bioinformatics in different areas of life sciences. It presents a compendium of many important topics of current advanced research and basic principles/approaches easily applicable to diverse research settings. The content encompasses topics such as biological databases, sequence analysis, genome assembly, RNA sequence data analysis, drug design, and structural and functional analysis of proteins. In addition, it discusses computational approaches for vaccine design, systems biology and big data analysis, and machine learning in bioinformatics. It is a valuable source for bioinformaticians, computer biologists, and members of biomedical field who needs to learn bioinformatics approaches to apply to their research and lab activities. Covers basic and more advanced developments of bioinformatics with a diverse and interdisciplinary approach to fulfill the needs of readers from different backgrounds Explains in a practical way how to decode complex biological problems using computational approaches and resources Brings case studies, real-world examples and several protocols to guide the readers with a problem-solving approach
Computers

Recent Trends in Computational Intelligence Enabled Research

Recent Trends in Computational Intelligence Enabled Research

Author: Siddhartha Bhattacharyya

Publisher: Academic Press

ISBN: 9780323851794

Category: Computers

Page: 418

View: 624

The field of computational intelligence has grown tremendously over that past five years, thanks to evolving soft computing and artificial intelligent methodologies, tools and techniques for envisaging the essence of intelligence embedded in real life observations. Consequently, scientists have been able to explain and understand real life processes and practices which previously often remain unexplored by virtue of their underlying imprecision, uncertainties and redundancies, and the unavailability of appropriate methods for describing the incompleteness and vagueness of information represented. With the advent of the field of computational intelligence, researchers are now able to explore and unearth the intelligence, otherwise insurmountable, embedded in the systems under consideration. Computational Intelligence is now not limited to only specific computational fields, it has made inroads in signal processing, smart manufacturing, predictive control, robot navigation, smart cities, and sensor design to name a few. Recent Trends in Computational Intelligence Enabled Research: Theoretical Foundations and Applications explores the use of this computational paradigm across a wide range of applied domains which handle meaningful information. Chapters investigate a broad spectrum of the applications of computational intelligence across different platforms and disciplines, expanding our knowledge base of various research initiatives in this direction. This volume aims to bring together researchers, engineers, developers and practitioners from academia and industry working in all major areas and interdisciplinary areas of computational intelligence, communication systems, computer networks, and soft computing. Provides insights into the theory, algorithms, implementation, and application of computational intelligence techniques Covers a wide range of applications of deep learning across various domains which are researching the applications of computational intelligence Investigates novel techniques and reviews the state-of-the-art in the areas of machine learning, computer vision, soft computing techniques
Science

Seed Development: OMICS Technologies toward Improvement of Seed Quality and Crop Yield

Seed Development: OMICS Technologies toward Improvement of Seed Quality and Crop Yield

Author: Ganesh K. Agrawal

Publisher: Springer Science & Business Media

ISBN: 9789400747494

Category: Science

Page: 576

View: 671

The book is about the seed development in the model and crop plants. Seed development is a key step of the plant life cycle that determines the nutrient value of seeds – the life for human civilization, growth, and development. The nutrient value of seeds is mainly due to storage reserve products such as carbohydrates, lipids (triacylglycerols), and proteins. The book primarily focuses on application of the 21st century high-throughput technologies transcriptomics, proteomics, metabolomics, and systems biology in near complete understanding of the various processes involved in seed development in different crop plants. The book reveals how such technologies have revolutionized our understanding of the multilayer processes and regulations involved therein by generating large-scale datasets. Accumulated datasets provide basic knowledge to develop integrated strategies to eventually improve the nutritional value of plant seed and crop yield, a critical goal in food security issues around the globe.
Science

Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications

Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications

Author: Joel Faintuch

Publisher: Academic Press

ISBN: 9780128152508

Category: Science

Page: 504

View: 875

Microbiome and Metabolome in Diagnosis, Therapy, and Other Strategic Applications is the first book to simultaneously cover the microbiome and the metabolome in relevant clinical conditions. In a pioneering fashion, it addresses not only the classic intestinal environment, but also the oral, gastric, lung, skin and vaginal microbiome that is in line with the latest investigations. Nonbacterial microbiomes, such as fungi and viruses are not overlooked, and the plasma microbiome is also discussed. As plasma, brain, placenta, tumor cells, and other sterile fluids and tissues, are increasingly recognized to potentially host a microbiome, albeit a limited one, this is a timely resource. The book's editors were fortunate to have the input of renowned collaborators from nearly all continents. This is truly an international effort that brings the latest in the field to students and professionals alike. Provides comprehensive coverage on diagnosis, therapy, pharmacotherapy and disease prevention in context of the microbiome and metabolome Focuses on the proposed physiological or pathological conditions Presents an up-to-date, useful reference

New Trends on Genome and Transcriptome Characterizations

New Trends on Genome and Transcriptome Characterizations

Author: Rosalba Giugno

Publisher: Frontiers Media SA

ISBN: 9782889456109

Category:

Page:

View: 178

Science

High-Performance Algorithms for Mass Spectrometry-Based Omics

High-Performance Algorithms for Mass Spectrometry-Based Omics

Author: Fahad Saeed

Publisher: Springer Nature

ISBN: 9783031019609

Category: Science

Page: 146

View: 597

To date, processing of high-throughput Mass Spectrometry (MS) data is accomplished using serial algorithms. Developing new methods to process MS data is an active area of research but there is no single strategy that focuses on scalability of MS based methods. Mass spectrometry is a diverse and versatile technology for high-throughput functional characterization of proteins, small molecules and metabolites in complex biological mixtures. In the recent years the technology has rapidly evolved and is now capable of generating increasingly large (multiple tera-bytes per experiment) and complex (multiple species/microbiome/high-dimensional) data sets. This rapid advance in MS instrumentation must be matched by equally fast and rapid evolution of scalable methods developed for analysis of these complex data sets. Ideally, the new methods should leverage the rich heterogeneous computational resources available in a ubiquitous fashion in the form of multicore, manycore, CPU-GPU, CPU-FPGA, and IntelPhi architectures. The absence of these high-performance computing algorithms now hinders scientific advancements for mass spectrometry research. In this book we illustrate the need for high-performance computing algorithms for MS based proteomics, and proteogenomics and showcase our progress in developing these high-performance algorithms.
Medical

Breast Cancer: Current Trends in Molecular Research

Breast Cancer: Current Trends in Molecular Research

Author: Shankar Suman

Publisher: Bentham Science Publishers

ISBN: 9781681089539

Category: Medical

Page: 287

View: 504

Breast cancer is one of the most common cancer types worldwide, and is a leading cause of cancer related deaths in women. In this book, medical experts review our current understanding of the molecular biology and characteristics of breast cancer. The topics covered in this book provide comprehensive knowledge of mechanisms underlying breast carcinogenesis, and are intended for a wide audience including scientists, teachers, and students. 11 chapters present information about several topics on breast cancer, including the role of cell growth and proliferation pathways, androgen and cytokine signaling, germline mutations in breast cancer susceptibility genes, and molecular factors causing invasive and metastatic breast cancer. In addition, the editors discuss the recent advancements in multi-omics data analysis based on inter-and intra-tumor molecular profiles. The reference highlights how the knowledge and understanding of the biological behavior of breast neoplasms have facilitated ongoing investigations into dietary polyphenolic compounds with antioxidant properties, making them function as cancer chemopreventive agents. Along with this, the current development of treatment strategies such as targeted molecular therapy, and radiation therapy is brought to the fore to update readers.

Fluxomics and Metabolic Analysis in Systems Microbiology

Fluxomics and Metabolic Analysis in Systems Microbiology

Author: Wei Xiong

Publisher: Frontiers Media SA

ISBN: 9782889630691

Category:

Page:

View: 244

Science

Advances in Soil Microbiology: Recent Trends and Future Prospects

Advances in Soil Microbiology: Recent Trends and Future Prospects

Author: Tapan Kumar Adhya

Publisher: Springer

ISBN: 9789811061783

Category: Science

Page: 204

View: 963

This book presents a comprehensive collection of articles illustrating the importance of microbial community structure and function for ecosystem sustainability and environmental reclamation. It addresses a diverse range of topics, including microbial diversity, physiology, genomics, ecosystem function, interaction, metabolism, and the fruitful use of microbial communities for crop productivity and environmental remediation. In addition, the book explores issues ranging from general concepts on the diversity of microorganisms in soil, and ecosystem function to the evolution and taxonomy of soil microbiota, with future prospects. It covers cutting-edge methods in soil microbial ecological studies, rhizosphere microflora, the role of organic matter in plant productivity, biological nitrogen fixation and its genetics, microbial transformation of plant nutrients in soil, plant-growth-promoting rhizobacteria, and organic matter transformation. The book also discusses the application of microbes in biodegradation of xenobiotic contaminants. It covers bio-fertilizers and their role in sustainable agriculture and soil health, biological control of insect pests and plant pathogens, and the latest tools of omics in soil microbiology, i.e. genomics, proteomics, transcriptomics and metabolomics, which offer pioneering approaches to the exploration of microbial structure and function.
Science

Omics Insights in Environmental Bioremediation

Omics Insights in Environmental Bioremediation

Author: Vineet Kumar

Publisher: Springer Nature

ISBN: 9789811943201

Category: Science

Page: 706

View: 275

Environmental pollution emanating from rapid industrialization, population growth, and urbanization has been considered a major problem in recent years that affects biodiversity, ecosystems, and human health by contaminating soil and water. This book brings out a comprehensive collection of information on valuable insights into different cutting-edge omics technologies, such as metagenomics, metatranscriptomics, metaproteomics, and metabolomics, along with advanced next-generation sequencing technologies as well as bioinformatic tools, which led to a better understanding of microbial communities and their adaptability to a wide range of contaminants and underlying their mechanisms in bioremediation and biodegradation of environmental pollutants. In addition, this edited volume provides critical insight into of potent microbial communities endowed with unique functional attributes through their unique metabolism catalyzed by ‘signature’ enzymes and degradation pathways. Step-by-step descriptions are provided of various microbial metabolic pathways of degradation and biotransformation of environmental contaminants by numerous illustrations which make the information easier to understand for the readers. Each chapter is devoted to selected examples of microbial bioremediation supported by tables, and an extensive list of references for readers interested in learning further details about the subject matter. This book is of interest to teachers, researchers to professionals, policymakers, stockholders, practitioners, environmental engineers, soil scientists, and policymakers. In addition, the book serves as additional comprehensive material for undergraduate, graduate, and doctoral students who require a working knowledge and knowhow of ‘Omics’ involved in and required for environmental remediation of legacy and emerging contaminants, will also find this to be a useful read.
Science

Recent Approaches in Omics for Plant Resilience to Climate Change

Recent Approaches in Omics for Plant Resilience to Climate Change

Author: Shabir Hussain Wani

Publisher: Springer

ISBN: 9783030216870

Category: Science

Page: 401

View: 190

This edited volume summarizes the recent advancements made in plant science including molecular biology and genome editing , particularly in the development of novel pathways tolerant to climate change-induced stresses such as drought, extreme temperatures, cold, salinity, flooding, etc. These stresses are liable for decrease in yields in many crop plants at global level. Till date conventional plant breeding approaches have resulted in significant improvement of crop plants for producing higher yields during adverse climatic conditions. However, the pace of improvement through conventional plant breeding needs to be accelerated in keeping with the growing demand of food and increasing human populationl, particularly in developing world. This book serves as a comprehensive reference material for researchers, teachers, and students involved in climate change-related abiotic stress tolerance studies in plants.